| | | |
| February 22, 2025 | T | Charlotte FC 2 at Seattle Sounders FC 2 | Final |
| March 1, 2025 | L | Seattle Sounders FC 0 at Real Salt Lake 2 | Final |
| March 8, 2025 | W | Los Angeles FC 2 at Seattle Sounders FC 5 | Final |
| March 15, 2025 | L | Seattle Sounders FC 0 at St. Louis City SC 1 | Final |
| March 22, 2025 | T | Houston Dynamo FC 0 at Seattle Sounders FC 0 | Final |
| March 29, 2025 | T | Seattle Sounders FC 1 at San Jose Earthquakes 1 | Final |
| April 5, 2025 | L | Seattle Sounders FC 0 at San Diego FC 3 | Final |
| April 12, 2025 | W | Seattle Sounders FC 1 at FC Dallas 0 | Final |
| April 19, 2025 | W | Nashville SC 0 at Seattle Sounders FC 3 | Final |
| April 26, 2025 | | Seattle Sounders FC at Colorado Rapids | 9:30 p.m. |
| May 3, 2025 | | St. Louis City SC at Seattle Sounders FC | 10:30 p.m. |
| May 10, 2025 | | Seattle Sounders FC at Houston Dynamo FC | 8:30 p.m. |
| May 14, 2025 | | Seattle Sounders FC at Los Angeles FC | 10:30 p.m. |
| May 17, 2025 | | Seattle Sounders FC at Portland Timbers | 9:30 p.m. |
| May 24, 2025 | | FC Dallas at Seattle Sounders FC | 3:00 p.m. |
| May 28, 2025 | | San Diego FC at Seattle Sounders FC | 8:30 p.m. |
| June 1, 2025 | | Minnesota United FC at Seattle Sounders FC | 6:00 p.m. |
| June 8, 2025 | | Seattle Sounders FC at Vancouver Whitecaps FC | 9:00 p.m. |
| June 28, 2025 | | Austin FC at Seattle Sounders FC | 10:30 p.m. |
| July 6, 2025 | | Columbus Crew SC at Seattle Sounders FC | 5:00 p.m. |
| July 12, 2025 | | Seattle Sounders FC at Sporting Kansas City | 8:30 p.m. |
| July 16, 2025 | | Colorado Rapids at Seattle Sounders FC | 9:30 p.m. |
| July 19, 2025 | | San Jose Earthquakes at Seattle Sounders FC | 8:30 p.m. |
| July 26, 2025 | | Seattle Sounders FC at Atlanta United FC | 7:30 p.m. |
| August 10, 2025 | | Seattle Sounders FC at LA Galaxy | 10:00 p.m. |
| August 16, 2025 | | Seattle Sounders FC at Minnesota United FC | 8:30 p.m. |
| August 24, 2025 | | Sporting Kansas City at Seattle Sounders FC | 9:00 p.m. |
| August 30, 2025 | | Real Salt Lake at Seattle Sounders FC | 10:30 p.m. |
| September 13, 2025 | | LA Galaxy at Seattle Sounders FC | 8:30 p.m. |
| September 16, 2025 | | Seattle Sounders FC at Inter Miami CF | 7:30 p.m. |
| September 20, 2025 | | Seattle Sounders FC at Austin FC | 8:30 p.m. |
| September 27, 2025 | | Vancouver Whitecaps FC at Seattle Sounders FC | 10:30 p.m. |
| October 4, 2025 | | Portland Timbers at Seattle Sounders FC | 10:30 p.m. |
| October 18, 2025 | | Seattle Sounders FC at New York City FC | 6:00 p.m. |
Seattle Sounders FC Schedule
