| | | |
| February 22, 2025 | W | Philadelphia Union 4 at Orlando City SC 2 | Final |
| March 1, 2025 | W | FC Cincinnati 1 at Philadelphia Union 4 | Final |
| March 8, 2025 | W | Philadelphia Union 2 at New England Revolution 0 | Final |
| March 16, 2025 | L | Nashville SC 3 at Philadelphia Union 1 | Final |
| March 22, 2025 | W | St. Louis City SC 0 at Philadelphia Union 1 | Final |
| March 29, 2025 | L | Philadelphia Union 1 at Inter Miami CF 2 | Final |
| April 5, 2025 | T | Orlando City SC 0 at Philadelphia Union 0 | Final |
| April 12, 2025 | L | Philadelphia Union 0 at New York City FC 1 | Final |
| April 19, 2025 | W | Atlanta United FC 0 at Philadelphia Union 3 | Final |
| April 26, 2025 | | D.C. United at Philadelphia Union | 4:30 p.m. |
| May 3, 2025 | | Philadelphia Union at Club de Foot Montreal | 7:30 p.m. |
| May 10, 2025 | | Columbus Crew SC at Philadelphia Union | 7:30 p.m. |
| May 14, 2025 | | LA Galaxy at Philadelphia Union | 7:30 p.m. |
| May 17, 2025 | | Philadelphia Union at Atlanta United FC | 7:30 p.m. |
| May 24, 2025 | | Inter Miami CF at Philadelphia Union | 7:30 p.m. |
| May 28, 2025 | | Philadelphia Union at Toronto FC | 7:30 p.m. |
| May 31, 2025 | | Philadelphia Union at FC Dallas | 8:30 p.m. |
| June 14, 2025 | | Charlotte FC at Philadelphia Union | 7:30 p.m. |
| June 25, 2025 | | Philadelphia Union at Chicago Fire FC | 8:30 p.m. |
| June 29, 2025 | | Philadelphia Union at Columbus Crew SC | 6:00 p.m. |
| July 5, 2025 | | Philadelphia Union at Nashville SC | 8:30 p.m. |
| July 12, 2025 | | New York Red Bulls at Philadelphia Union | 7:30 p.m. |
| July 16, 2025 | | Club de Foot Montreal at Philadelphia Union | 7:30 p.m. |
| July 19, 2025 | | Philadelphia Union at Houston Dynamo FC | 8:30 p.m. |
| July 26, 2025 | | Colorado Rapids at Philadelphia Union | 7:30 p.m. |
| August 9, 2025 | | Toronto FC at Philadelphia Union | 7:30 p.m. |
| August 16, 2025 | | Philadelphia Union at New York Red Bulls | 7:30 p.m. |
| August 23, 2025 | | Chicago Fire FC at Philadelphia Union | 7:30 p.m. |
| August 30, 2025 | | Philadelphia Union at FC Cincinnati | 7:30 p.m. |
| September 13, 2025 | | Philadelphia Union at Vancouver Whitecaps FC | 9:30 p.m. |
| September 20, 2025 | | New England Revolution at Philadelphia Union | 2:30 p.m. |
| September 27, 2025 | | Philadelphia Union at D.C. United | 7:30 p.m. |
| October 4, 2025 | | New York City FC at Philadelphia Union | 7:30 p.m. |
| October 18, 2025 | | Philadelphia Union at Charlotte FC | 6:00 p.m. |
Philadelphia Union Schedule
