| | | |
| March 15, 2025 | T | NJ/NY Gotham FC 1 at Seattle Reign FC 1 | Final |
| March 22, 2025 | W | Seattle Reign FC 2 at North Carolina Courage 1 | Final |
| March 30, 2025 | L | Seattle Reign FC 1 at Angel City FC 2 | Final |
| April 12, 2025 | L | Orlando Pride 1 at Seattle Reign FC 0 | Final |
| April 18, 2025 | W | Portland Thorns FC 0 at Seattle Reign FC 1 | Final |
| April 26, 2025 | | Seattle Reign FC at Bay FC | 10:00 p.m. |
| May 2, 2025 | | Kansas City Current at Seattle Reign FC | 10:30 p.m. |
| May 11, 2025 | | Houston Dash at Seattle Reign FC | 8:00 p.m. |
| May 16, 2025 | | Seattle Reign FC at Racing Louisville FC | 7:30 p.m. |
| May 23, 2025 | | Washington Spirit at Seattle Reign FC | 10:00 p.m. |
| June 6, 2025 | | Seattle Reign FC at San Diego Wave FC | 10:00 p.m. |
| June 14, 2025 | | Seattle Reign FC at Chicago Stars FC | 5:00 p.m. |
| June 21, 2025 | | Seattle Reign FC at Utah Royals FC | 5:00 p.m. |
| August 1, 2025 | | Angel City FC at Seattle Reign FC | 10:30 p.m. |
| August 10, 2025 | | Seattle Reign FC at Portland Thorns FC | 4:00 p.m. |
| August 18, 2025 | | Chicago Stars FC at Seattle Reign FC | 10:00 p.m. |
| August 24, 2025 | | Seattle Reign FC at Houston Dash | 7:00 p.m. |
| August 29, 2025 | | San Diego Wave FC at Seattle Reign FC | 10:30 p.m. |
| September 7, 2025 | | Seattle Reign FC at Washington Spirit | 4:00 p.m. |
| September 14, 2025 | | Racing Louisville FC at Seattle Reign FC | 8:00 p.m. |
| September 20, 2025 | | Seattle Reign FC at Kansas City Current | 7:30 p.m. |
| September 28, 2025 | | North Carolina Courage at Seattle Reign FC | 8:00 p.m. |
| October 5, 2025 | | Seattle Reign FC at NJ/NY Gotham FC | 4:00 p.m. |
| October 10, 2025 | | Bay FC at Seattle Reign FC | 10:30 p.m. |
| October 17, 2025 | | Utah Royals FC at Seattle Reign FC | 10:00 p.m. |
| November 2, 2025 | | Seattle Reign FC at Orlando Pride | TBD |
Seattle Reign FC Schedule
