| | | |
| February 22, 2025 | T | New York City FC 2 at Inter Miami CF 2 | Final |
| March 1, 2025 | L | New York City FC 0 at Los Angeles FC 1 | Final |
| March 8, 2025 | W | Orlando City SC 1 at New York City FC 2 | Final |
| March 15, 2025 | W | New England Revolution 1 at New York City FC 2 | Final |
| March 22, 2025 | T | New York City FC 0 at Columbus Crew SC 0 | Final |
| March 29, 2025 | L | New York City FC 3 at Atlanta United FC 4 | Final |
| April 6, 2025 | L | Minnesota United FC 2 at New York City FC 1 | Final |
| April 12, 2025 | W | Philadelphia Union 0 at New York City FC 1 | Final |
| April 19, 2025 | L | New York City FC 0 at New England Revolution 2 | Final |
| April 26, 2025 | | New York City FC at Toronto FC | 2:30 p.m. |
| May 4, 2025 | | FC Cincinnati at New York City FC | 3:00 p.m. |
| May 10, 2025 | | Club de Foot Montreal at New York City FC | 7:30 p.m. |
| May 14, 2025 | | New York City FC at D.C. United | 7:30 p.m. |
| May 17, 2025 | | New York Red Bulls at New York City FC | 4:30 p.m. |
| May 25, 2025 | | Chicago Fire FC at New York City FC | 3:00 p.m. |
| May 28, 2025 | | Houston Dynamo FC at New York City FC | 7:30 p.m. |
| May 31, 2025 | | New York City FC at Nashville SC | 4:30 p.m. |
| June 12, 2025 | | Atlanta United FC at New York City FC | 7:30 p.m. |
| June 28, 2025 | | New York City FC at Club de Foot Montreal | 7:30 p.m. |
| July 3, 2025 | | Toronto FC at New York City FC | 7:30 p.m. |
| July 12, 2025 | | New York City FC at Charlotte FC | 7:30 p.m. |
| July 16, 2025 | | New York City FC at Orlando City SC | 7:30 p.m. |
| July 19, 2025 | | New York City FC at Sporting Kansas City | 8:30 p.m. |
| July 25, 2025 | | New York City FC at FC Dallas | 8:30 p.m. |
| August 9, 2025 | | Columbus Crew SC at New York City FC | 7:30 p.m. |
| August 17, 2025 | | Nashville SC at New York City FC | 5:00 p.m. |
| August 23, 2025 | | New York City FC at FC Cincinnati | 7:30 p.m. |
| August 30, 2025 | | D.C. United at New York City FC | 7:30 p.m. |
| September 13, 2025 | | New York City FC at Chicago Fire FC | 8:30 p.m. |
| September 19, 2025 | | Charlotte FC at New York City FC | 7:30 p.m. |
| September 24, 2025 | | Inter Miami CF at New York City FC | 7:30 p.m. |
| September 27, 2025 | | New York City FC at New York Red Bulls | 7:30 p.m. |
| October 4, 2025 | | New York City FC at Philadelphia Union | 7:30 p.m. |
| October 18, 2025 | | Seattle Sounders FC at New York City FC | 6:00 p.m. |
New York City FC Schedule
