| | | |
| March 28, 2025 | L | St. Louis Battlehawks 31 at Houston Roughnecks 6 | Final |
| April 6, 2025 | L | Houston Roughnecks 9 at Arlington Renegades 11 | Final |
| April 12, 2025 | W | Houston Roughnecks 18 at Memphis Showboats 17 | Final |
| April 19, 2025 | L | Birmingham Stallions 23 at Houston Roughnecks 16 | Final |
| April 27, 2025 | W | Houston Roughnecks 27 at San Antonio Brahmas 3 | Final |
| May 3, 2025 | | Memphis Showboats at Houston Roughnecks | 12:00 p.m. |
| May 11, 2025 | | Houston Roughnecks at Birmingham Stallions | 12:00 p.m. |
| May 17, 2025 | | Michigan Panthers at Houston Roughnecks | 1:00 p.m. |
| May 25, 2025 | | D.C. Defenders at Houston Roughnecks | 4:00 p.m. |
| May 31, 2025 | | Houston Roughnecks at Michigan Panthers | 3:00 p.m. |
Houston Roughnecks Schedule
