| | | |
| March 28, 2025 | W | Rochester Red Wings 2 at Buffalo Bisons 6 | Final |
| March 29, 2025 | L | Rochester Red Wings 8 at Buffalo Bisons 3 | Final (8) |
| March 30, 2025 | | Rochester Red Wings at Buffalo Bisons | Ppd. |
| April 1, 2025 | L | Buffalo Bisons 7 at Memphis Redbirds 13 | Final |
| April 2, 2025 | L | Buffalo Bisons 3 at Memphis Redbirds 15 | Final |
| April 3, 2025 | | Buffalo Bisons at Memphis Redbirds | Ppd. |
| April 4, 2025 | L | Buffalo Bisons 1 at Memphis Redbirds 4 (Game 1) | Final (7) |
| April 4, 2025 | L | Buffalo Bisons 1 at Memphis Redbirds 3 (Game 2) | Final (7) |
| April 5, 2025 | | Buffalo Bisons at Memphis Redbirds | Ppd. |
| April 6, 2025 | | Buffalo Bisons at Memphis Redbirds (Game 1) | Cancelled |
| April 6, 2025 | | Buffalo Bisons at Memphis Redbirds (Game 2) | Cancelled |
| April 8, 2025 | | Durham Bulls at Buffalo Bisons | Ppd. |
| April 9, 2025 | L | Durham Bulls 7 at Buffalo Bisons 1 (Game 1) | Final (7) |
| April 9, 2025 | W | Durham Bulls 1 at Buffalo Bisons 2 (Game 2) | Final (7) |
| April 10, 2025 | | Durham Bulls at Buffalo Bisons | Ppd. |
| April 11, 2025 | W | Durham Bulls 5 at Buffalo Bisons 8 | Final |
| April 12, 2025 | L | Durham Bulls 4 at Buffalo Bisons 1 (Game 1) | Final (7) |
| April 12, 2025 | L | Durham Bulls 2 at Buffalo Bisons 1 (Game 2) | Final (7) |
| April 13, 2025 | W | Durham Bulls 3 at Buffalo Bisons 5 | Final |
| April 15, 2025 | L | Buffalo Bisons 2 at Syracuse Mets 10 | Final (6) |
| April 16, 2025 | | Buffalo Bisons at Syracuse Mets | Ppd. |
| April 17, 2025 | L | Buffalo Bisons 0 at Syracuse Mets 2 | Final |
| April 18, 2025 | L | Buffalo Bisons 0 at Syracuse Mets 3 (Game 1) | Final (7) |
| April 18, 2025 | L | Buffalo Bisons 5 at Syracuse Mets 11 (Game 2) | Final (7) |
| April 19, 2025 | W | Buffalo Bisons 5 at Syracuse Mets 1 | Final |
| April 20, 2025 | L | Buffalo Bisons 1 at Syracuse Mets 2 | Final |
| April 22, 2025 | L | Rochester Red Wings 8 at Buffalo Bisons 4 | Final (11) |
| April 23, 2025 | W | Rochester Red Wings 3 at Buffalo Bisons 6 (Game 1) | Final (7) |
| April 23, 2025 | W | Rochester Red Wings 2 at Buffalo Bisons 3 (Game 2) | Final (7) |
| April 24, 2025 | W | Rochester Red Wings 1 at Buffalo Bisons 8 | Final |
| April 25, 2025 | | Rochester Red Wings 1 at Buffalo Bisons 0 | Top 3rd |
| April 26, 2025 | | Rochester Red Wings at Buffalo Bisons | 1:05 p.m. |
| April 27, 2025 | | Rochester Red Wings at Buffalo Bisons | 1:05 p.m. |
| April 29, 2025 | | Buffalo Bisons at Iowa Cubs | 7:38 p.m. |
| April 30, 2025 | | Buffalo Bisons at Iowa Cubs | 1:08 p.m. |
| May 1, 2025 | | Buffalo Bisons at Iowa Cubs | 1:08 p.m. |
| May 2, 2025 | | Buffalo Bisons at Iowa Cubs | 8:08 p.m. |
| May 3, 2025 | | Buffalo Bisons at Iowa Cubs | 4:08 p.m. |
| May 4, 2025 | | Buffalo Bisons at Iowa Cubs | 2:08 p.m. |
| May 6, 2025 | | Buffalo Bisons at St. Paul Saints | 7:37 p.m. |
| May 7, 2025 | | Buffalo Bisons at St. Paul Saints | 7:37 p.m. |
| May 8, 2025 | | Buffalo Bisons at St. Paul Saints | 7:37 p.m. |
| May 9, 2025 | | Buffalo Bisons at St. Paul Saints | 7:37 p.m. |
| May 10, 2025 | | Buffalo Bisons at St. Paul Saints | 3:07 p.m. |
| May 11, 2025 | | Buffalo Bisons at St. Paul Saints | 3:07 p.m. |
| May 13, 2025 | | Worcester Red Sox at Buffalo Bisons | 6:05 p.m. |
| May 14, 2025 | | Worcester Red Sox at Buffalo Bisons | 6:05 p.m. |
| May 15, 2025 | | Worcester Red Sox at Buffalo Bisons | 6:05 p.m. |
| May 16, 2025 | | Worcester Red Sox at Buffalo Bisons | 6:05 p.m. |
| May 17, 2025 | | Worcester Red Sox at Buffalo Bisons | 1:05 p.m. |
| May 18, 2025 | | Worcester Red Sox at Buffalo Bisons | 1:05 p.m. |
| May 20, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | 11:00 a.m. |
| May 21, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | 6:45 p.m. |
| May 22, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | 6:45 p.m. |
| May 23, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | 7:05 p.m. |
| May 24, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | 6:35 p.m. |
| May 25, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | 6:35 p.m. |
| May 27, 2025 | | Charlotte Knights at Buffalo Bisons | 6:05 p.m. |
| May 28, 2025 | | Charlotte Knights at Buffalo Bisons | 1:05 p.m. |
| May 29, 2025 | | Charlotte Knights at Buffalo Bisons | 11:05 a.m. |
| May 30, 2025 | | Charlotte Knights at Buffalo Bisons | 6:35 p.m. |
| May 31, 2025 | | Charlotte Knights at Buffalo Bisons | 6:05 p.m. |
| June 1, 2025 | | Charlotte Knights at Buffalo Bisons | 1:05 p.m. |
| June 3, 2025 | | Buffalo Bisons at Syracuse Mets | 6:35 p.m. |
| June 4, 2025 | | Buffalo Bisons at Syracuse Mets | 6:35 p.m. |
| June 5, 2025 | | Buffalo Bisons at Syracuse Mets | 6:35 p.m. |
| June 6, 2025 | | Buffalo Bisons at Syracuse Mets | 6:35 p.m. |
| June 7, 2025 | | Buffalo Bisons at Syracuse Mets | 6:35 p.m. |
| June 8, 2025 | | Buffalo Bisons at Syracuse Mets | 1:05 p.m. |
| June 10, 2025 | | Columbus Clippers at Buffalo Bisons | 6:35 p.m. |
| June 11, 2025 | | Columbus Clippers at Buffalo Bisons | 6:35 p.m. |
| June 12, 2025 | | Columbus Clippers at Buffalo Bisons | 6:35 p.m. |
| June 13, 2025 | | Columbus Clippers at Buffalo Bisons | 6:35 p.m. |
| June 14, 2025 | | Columbus Clippers at Buffalo Bisons | 6:35 p.m. |
| June 15, 2025 | | Columbus Clippers at Buffalo Bisons | 1:05 p.m. |
| June 17, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| June 18, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| June 19, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| June 20, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| June 21, 2025 | | Buffalo Bisons at Worcester Red Sox | 4:05 p.m. |
| June 22, 2025 | | Buffalo Bisons at Worcester Red Sox | 1:05 p.m. |
| June 24, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| June 25, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 1:05 p.m. |
| June 26, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| June 27, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| June 28, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| June 29, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 1:05 p.m. |
| July 1, 2025 | | Rochester Red Wings at Buffalo Bisons | 6:35 p.m. |
| July 2, 2025 | | Rochester Red Wings at Buffalo Bisons | 6:35 p.m. |
| July 3, 2025 | | Rochester Red Wings at Buffalo Bisons | 6:05 p.m. |
| July 4, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:45 p.m. |
| July 5, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:05 p.m. |
| July 6, 2025 | | Buffalo Bisons at Rochester Red Wings | 1:05 p.m. |
| July 8, 2025 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 9, 2025 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| July 10, 2025 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 11, 2025 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 12, 2025 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| July 13, 2025 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| July 18, 2025 | | Omaha Storm Chasers at Buffalo Bisons | 6:35 p.m. |
| July 19, 2025 | | Omaha Storm Chasers at Buffalo Bisons | 6:35 p.m. |
| July 20, 2025 | | Omaha Storm Chasers at Buffalo Bisons | 1:05 p.m. |
| July 22, 2025 | | Buffalo Bisons at Columbus Clippers | 7:05 p.m. |
| July 23, 2025 | | Buffalo Bisons at Columbus Clippers | 7:05 p.m. |
| July 24, 2025 | | Buffalo Bisons at Columbus Clippers | 12:05 p.m. |
| July 25, 2025 | | Buffalo Bisons at Columbus Clippers | 6:35 p.m. |
| July 26, 2025 | | Buffalo Bisons at Columbus Clippers | 7:05 p.m. |
| July 27, 2025 | | Buffalo Bisons at Columbus Clippers | 1:05 p.m. |
| July 29, 2025 | | Syracuse Mets at Buffalo Bisons | 6:35 p.m. |
| July 30, 2025 | | Syracuse Mets at Buffalo Bisons | 1:05 p.m. |
| July 31, 2025 | | Syracuse Mets at Buffalo Bisons | 6:35 p.m. |
| August 1, 2025 | | Syracuse Mets at Buffalo Bisons | 6:35 p.m. |
| August 2, 2025 | | Syracuse Mets at Buffalo Bisons | 6:35 p.m. |
| August 3, 2025 | | Syracuse Mets at Buffalo Bisons | 1:05 p.m. |
| August 5, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| August 6, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| August 7, 2025 | | Buffalo Bisons at Worcester Red Sox | 12:05 p.m. |
| August 8, 2025 | | Buffalo Bisons at Worcester Red Sox | 6:45 p.m. |
| August 9, 2025 | | Buffalo Bisons at Worcester Red Sox | 4:05 p.m. |
| August 10, 2025 | | Buffalo Bisons at Worcester Red Sox | 1:05 p.m. |
| August 12, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| August 13, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 1:05 p.m. |
| August 14, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| August 15, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| August 16, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 6:35 p.m. |
| August 17, 2025 | | Lehigh Valley IronPigs at Buffalo Bisons | 1:05 p.m. |
| August 19, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:35 p.m. |
| August 20, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 1:05 p.m. |
| August 21, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:35 p.m. |
| August 22, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:35 p.m. |
| August 23, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:35 p.m. |
| August 24, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 1:05 p.m. |
| August 26, 2025 | | Buffalo Bisons at Indianapolis Indians | 6:35 p.m. |
| August 27, 2025 | | Buffalo Bisons at Indianapolis Indians | 6:35 p.m. |
| August 28, 2025 | | Buffalo Bisons at Indianapolis Indians | 6:35 p.m. |
| August 29, 2025 | | Buffalo Bisons at Indianapolis Indians | 7:05 p.m. |
| August 30, 2025 | | Buffalo Bisons at Indianapolis Indians | 6:35 p.m. |
| August 31, 2025 | | Buffalo Bisons at Indianapolis Indians | 1:35 p.m. |
| September 2, 2025 | | Syracuse Mets at Buffalo Bisons | 6:05 p.m. |
| September 3, 2025 | | Syracuse Mets at Buffalo Bisons | 6:05 p.m. |
| September 4, 2025 | | Syracuse Mets at Buffalo Bisons | 1:05 p.m. |
| September 5, 2025 | | Syracuse Mets at Buffalo Bisons | 6:05 p.m. |
| September 6, 2025 | | Syracuse Mets at Buffalo Bisons | 1:05 p.m. |
| September 7, 2025 | | Syracuse Mets at Buffalo Bisons | TBD |
| September 9, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:05 p.m. |
| September 10, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:05 p.m. |
| September 11, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:05 p.m. |
| September 12, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:05 p.m. |
| September 13, 2025 | | Buffalo Bisons at Rochester Red Wings | 6:05 p.m. |
| September 14, 2025 | | Buffalo Bisons at Rochester Red Wings | 1:05 p.m. |
| September 16, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:05 p.m. |
| September 17, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:05 p.m. |
| September 18, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 1:05 p.m. |
| September 19, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:05 p.m. |
| September 20, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 1:05 p.m. |
| September 21, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | TBD |
Buffalo Bisons Schedule
